Frontline spray

Can anyone tell me if they have ever had a problem with this product.
We encountered a problem with fleas this year and never have had them before. The vet recommended using this on my 11 year old Greyhound so on Thursday we sprayed him with it and on Sunday he quit eating his meals, he only takes a bite or two and then quits eating, that is usually the hunk that I have his antibiotic in which is for a skin infection that he has.

This is starting to worry me because my Malamute has been bathing him none stop for the last couple of months like she is trying to heal him, so I have felt that there is something wrong with him, even though the vet checked him over and couldn’t find anything except the skin infection and fleas, but the Malamute also bathed my other Greyhound for a long period of time before he died. I don’t know if he has just became picky or what, but he has never turned down a meal, he is still eating his treats with no problem.
Thank you in advance for any help that you may give me.

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